Trigeminal neuropathic pain is a chronic pain condition caused by damage or\ninflammation of the trigeminal nerve or its branches, with both peripheral and central nervous\nsystem dysfunction contributing to the disorder. Trigeminal pain conditions present with diagnostic\nand therapeutic challenges to healthcare providers and often require multiple therapeutic\napproaches for pain reduction. This review will provide the overview of pathophysiology in\nperipheral and central nociceptive circuits that are involved in neuropathic pain conditions\ninvolving the trigeminal nerve and the current therapeutics that are used to treat these disorders.\nRecent advances in treatment of trigeminal pain, including novel therapeutics that target ion\nchannels and receptors, gene therapy and monoclonal antibodies that have shown great promise in\npreclinical studies and clinical trials will also be described.
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